DSPE-MPEG 结构式:
DSPE-PEG聚乙二醇磷脂是既具有亲水性又具有疏水性的磷脂PEG缀合物,具有良好的物理性质和生物相容性;聚乙二醇磷脂能显著改善血液循环时间和胶囊化药物的稳定性,所以它是形成脂质体的优良材料,应用于基因转染、药物运输和疫苗传递,还可通过用靶向配体(例如抗体,肽)修饰其表面来用于靶向药物递送,亦用于修饰有机小分子药物、生物材料等。
DSPE-PEG polyethylene glycol phospholipid is a phospholipid peg conjugate with both hydrophilicity and hydrophobicity, which has good physical properties and biocompatibility; Polyethylene glycol phospholipid can significantly improve the blood circulation time and the stability of encapsulated drugs. Therefore, it is an excellent material for forming liposomes, which can be used for gene transfection, drug transport and vaccine delivery. It can also be used for targeted drug delivery by modifying its surface with targeted ligands (such as antibodies and peptides), and also for modifying organic small molecule drugs and biomaterials.
参考文献
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