为华生物DOPE-PEG-NH2 二油酰磷脂酰乙醇胺-聚乙二醇-氨基的简介和应用说明

(DOPE)共轭聚乙二醇是磷脂和聚乙二醇结合,具有亲水性和疏水性。聚乙二醇磷脂脂质体形成 材料,可用于药物输送、基因转染和疫苗传递。聚乙二醇能增强溶解性和稳定性,降低带电分子表面非特异性结合,降低多肽的免疫原性。PEG末端氨基可以修饰带有羧基/活性酯等基团的氨基酸,多肽,蛋白质等。这些材料还可用于靶向给药通过修改与目标表面配体如抗体、多肽。

PEG末端氨基可以修饰带有羧基/活性酯等基团的氨基酸，多肽，蛋白质等。氨基可以很容易的和羧基形成稳定的酰胺键,也可以和活性酯(-NHS)在PH7-8.5形成酰胺键。

(dope) conjugated polyethylene glycol is a combination of phospholipid and polyethylene glycol with hydrophilicity and hydrophobicity. Polyethylene glycol phospholipid liposome forming material can be used for drug delivery, gene transfection and vaccine delivery. Polyethylene glycol can enhance the solubility and stability, reduce the non-specific binding of charged molecules, and reduce the immunogenicity of peptides. Peg terminal amino groups can modify amino acids, polypeptides and proteins with carboxyl / active ester groups. These materials can also be used for targeted drug delivery by modifying ligands with the target surface such as antibodies, polypeptides.

Peg terminal amino groups can modify amino acids, polypeptides and proteins with carboxyl / active ester groups. Amino groups can easily form stable amide bonds with carboxyl groups, and can also form amide bonds with active esters (- NHS) at pH 7-8.5.

仅供科研，禁止用于人体