为华生物的功能化PEG磷脂，脂质体首选材料

2-Distearoyl-sn-Glycero-3-Phosphoethanolamine(DSPE)共轭聚乙二醇是磷脂和聚乙二醇结合具有亲水性和疏水性。聚乙二醇磷脂脂质体形成材料,可用于药用辅料；输送、基因转染和疫苗传递。具有乳化、药物增容的作用，近年来脂质体、脂肪乳、纳米粒等缓控释药物制剂的重要材料。聚乙二醇化磷脂能显著改善血液循环时间和稳定封装药物。对磷脂分子进行修饰，也具备使制剂在特定条件下释放和靶向定位的能力。

通常修饰的方式有

1、引入聚合物改善制剂的血循环时间、崩解时间

2、引入免疫因子增强靶向性

3、引入标记物用以诊断和追踪

PEG聚乙二醇是常用于改善磷脂性能的一种聚合物，末端可以进一步修饰，用来连接多肽、抗体、核酸等等，使得PEG磷脂载体具有免疫靶向性，这一类磷脂就称之为功能化PEG磷脂

(DSPE)conjugated polyethylene glycol is a combination of phospholipid and polyethylene glycol with hydrophilicity and hydrophobicity. Polyethylene glycol phospholipid liposome forming material can be used as pharmaceutical excipients; Delivery, gene transfection and vaccine delivery. It has the function of emulsification and drug compatibilization. In recent years, it is an important material for slow-release and controlled-release drug preparations such as liposomes, fat emulsions and nanoparticles. Pegylated phospholipids can significantly improve blood circulation time and stably encapsulate drugs. The modification of phospholipid molecules also has the ability to release and target the preparation under specific conditions.

The usual ways of modification are:

1. The introduction of polymer improves the blood circulation time and disintegration time of the preparation

2. Introduction of immune factors to enhance targeting

3. Introduction of markers for diagnosis and tracking

Peg polyethylene glycol is a polymer commonly used to improve the performance of phospholipids. The end can be further modified to connect polypeptides, antibodies, nucleic acids, etc., so that PEG phospholipid carriers have immune targeting. This kind of phospholipids is called functionalized peg phospholipids