为华生物分享PEG磷脂（DSPE-PEG）的SH、Biotin、MAL、COOH封端

PEG磷脂发挥怎样的作用？

磷脂用作药用辅料具有乳化、药物增溶的作用，是脂质体、脂肪乳、纳米粒等缓控释药物制剂重要的材料。对磷脂分子进行修饰，可以使这些制剂具备特定条件释放、靶向定位的能力。常用的修饰方法包括：引入聚合物改善制剂的血循环时间、崩解时间；引入免疫因子增强靶向性；引入标记物用以诊断和追踪等。功能化PEG磷脂，是聚乙二醇(PEG)的末端可以进一步的修饰用以连接多肽、核酸等配体，是常用的一种改善磷脂性能的聚合物；PEG磷脂载体具有免疫靶向性，具有营养、治疗作用的磷脂用作药用辅料。

现在已经有多种PEG磷脂作为抗肿瘤药物制剂进入临床试验阶段。为华生物给大家介绍其中的几款:SH、Biotin、Mal、COOH、

DSPE-PEG2000-SH，巯基封端

DSPE-PEG2000-Biotin，生物素封端

DSPE-PEG2000-Mal，马来酰亚胺封端

DSPE-PEG2000-COOH，羧酸封端

除此之外为华生物还带来一些荧光分子，例如FITC、Rhodamine、CY3、CY5等等

Phospholipids as pharmaceutical excipients have the functions of emulsification and drug solubilization, and are important materials for liposomes, fat emulsions, nanoparticles and other slow-release and controlled-release drug preparations. The modification of phospholipid molecules can make these preparations have the ability of specific release and targeting. Common modification methods include: introducing polymer to improve the blood circulation time and disintegration time of the preparation; Introducing immune factors to enhance targeting; Introducing markers for diagnosis and tracking. Functionalized peg phospholipids, which can be further modified at the end of polyethylene glycol (PEG) to connect polypeptides, nucleic acids and other ligands, are commonly used polymers to improve the performance of phospholipids; Peg phospholipid carrier has immune targeting, and phospholipids with nutritional and therapeutic effects are used as pharmaceutical excipients.