为华生物PLA-PEG-NH2 聚乳酸聚乙二醇氨基的简介和应用说明

氨基可以与羧基生成酰胺键，也可以与活性酯反应。聚乙二醇增加药物溶解度和稳定性，减少多肽和蛋白质的免疫原性， 抑制带电分子在修饰表面的非特异性结合。可修饰蛋白质、多肽和其它小分子材料。广泛应用于医药研究、药性缓释、纳米新材料研究、细胞培养。在活性化合物的配体研究，多肽合成载体，高分子接枝化合物，新型材料的聚乙二醇涂层及修饰功能化方面的应用成为研究趋势。一般用于聚合物胶束、纳米粒的制备；嵌段共聚物,可以作为不同种类药物的载体材料,并提高药物的水溶性以及包封率和载药量,可制成载药的微球、微囊、囊泡、胶束,用于实现药物的缓释、控释,也可作为成亲水性较好的组织工程支架材料。PEG可增加溶解度和稳定性。

Amino groups can form amide bonds with carboxyl groups or react with active esters. Polyethylene glycol increases drug solubility and stability, reduces immunogenicity of peptides and proteins, and inhibits non-specific binding of charged molecules on modified surfaces. Proteins, polypeptides and other small molecular materials can be modified. It is widely used in pharmaceutical research, drug release, nano new materials research and cell culture. It has become a research trend in ligand research of active compounds, polypeptide synthesis carriers, polymer graft compounds, polyethylene glycol coating of new materials and modification functionalization. Generally used for the preparation of polymer micelles and nanoparticles; Block copolymers can be used as carrier materials for different kinds of drugs, and improve the water solubility, entrapment efficiency and drug loading capacity of drugs. They can be made into microspheres, microcapsules, vesicles and micelles loaded with drugs, which can be used to achieve sustained and controlled release of drugs. They can also be used as tissue engineering scaffolds with good hydrophilicity. Peg can increase solubility and stability.

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